Naphazoline belongs to the imidazoline class of sympathomimetics. : HY-B0446 CAS No. Pharmacokinetics. slow heartbeat. Hydrochloric acid poisoning. In high doses or when ingested, naphazoline can lead to central nervous system … Use this medication in the nose as directed. Substances predicted as likely to meet criteria for category 1A or 1B carcinogenicity, mutagenicity, or reproductive toxicity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. Use of Naphazoline hydrochloride Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.Target: Adrenergic Receptorphazoline hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses. Decrease in body temperature. : 550-99-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. Am J Dis Child. A conscious rabbit was injected with naphazoline and thereafter with atropine. Naphcon A (naphazoline hydrochloride and pheniramine maleate) is a combination of a decongestant /redness reliever and an antihistamine used for the temporary relief of redness and itching of the eye (s) due to ragweed pollen, grass, and animal dander and hair. Reactive hyperaemia and atrophic rhinitis sicca are well-known local side effects. Upon ocular administration, naphazoline exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness. Hydrochloric acid is a clear, poisonous liquid. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 NAPHAZOLINE hydrochloride N. N. R. ("privine hydrochloride") was introduced in 1942; since that time it has become one of the widely used nasal vasoconstrictors. Half-life of tetryzoline in healthy people is about 6 hours and it is excreted unchanged in urine, at least in part. It is a sympathomimetic agent with marked alpha adrenergic activity. 1948;75(1):76-80. Atropine doubled HR, but caused a marked rise in MAP, too, stressing the adverse effects of atropine in these cases. There is no antidote for tetryzoline or other similar imidazoline analogue poisoning, but the symptoms can be alleviated and with treatment, death is rare. Acute pulmonary edema associated with naphazoline ingestion. Follow all directions on the product package, or use as directed by your doctor. 47. Naphazoline HCl prescription and dosage sizes information for physicians and healthcare professionals. Combination of an ocular antihistamine and decongestant. Due to its α-symphathomimetic effect, this agent has topical and systemic side effects. Naphazoline is a decongestant. 2008 Mar. Drug Name Active Ingredients Strength Dosage Form/Route Marketing Status TE Code RLD RS; NAPHCON-A: NAPHAZOLINE HYDROCHLORIDE; PHENIRAMINE MALEATE: 0.025%;0.3% Fortunately, its toxic reactions have been confined to mild local and rare systemic effects.The following case … 2015/830 and US OSHA HCS 2015 1.1 Product Code: 23774 Section 1. Naphazoline is a vasoconstrictor. Immediate veterinary attention should be sought following ingestion. 17852165. Even a small ingestion can cause clinical signs of vomiting, lethargy/depression or agitation, ataxia (incoordination), hypotension, and a life-threatening low heart rate. : 550-99-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Inappropriate use or unintentional ingestion of naphazoline can quickly cause Pharmacology, adverse reactions, warnings and side effects. Yamadori Y, Oiso N, Hirao A, Kawara S, Kawada A. Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over-the-counter topical antiseptic. Naphazoline is an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive activity. I.v. weakness (severe) Some side effects may occur that usually do not need medical attention. Toxicity. naphazoline doubled mean arterial pressure (MAP) and reduced heart rate (HR) from 167 to 30 beats/min. This medication is used to temporarily relieve eye redness, puffiness, itching, and watering that commonly occur with allergies. This article is for information only. Naphazoline Hydrochloride, an ocular vasoconstrictor, is an imidazoline derivative sympathomimetic amine. 19253271 [Microhemocirculation and its correction in duodenal ulcer during period of rehabilitation]. Structure. It occurs as a white, odorless crystalline powder having a bitter taste and is freely soluble in water and in alcohol. Product name : Naphazoline hydrochloride CAS-No. Product name : Naphazoline (hydrochloride) Catalog No. How to use Naphazoline Spray, Non-Aerosol. Accidental poisoning with naphazoline («PRIVINE») hydrochlorid. 550-99-2 - DJDFFEBSKJCGHC-UHFFFAOYSA-N - Naphazoline hydrochloride [USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information. The reports on this medication suggest a charcoal lavage to bind the toxins, and supportive care which will include an anti nausea medication and fluids. Use should be discontinued if symptoms worsen or persist for more than 72 hours. It is a caustic chemical and highly corrosive, which means it immediately causes severe damage to tissues, such as burning, on contact. ... Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride. It works by narrowing swollen blood vessels in the eyes to reduce eye redness. Naphazoline is a medicine used as a decongestant.It is a sympathomimetic agent with marked alpha adrenergic activity. 1907/2006 as amended by (EC) No. In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately. Winston C. Hainsworth. Human Resources for the University of Oklahoma. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Naphazoline (hydrochloride) Symptoms of overdose. Used for the temporary relief of redness and itching of the eye due to pollen, ragweed, grass, animal hair and dander. In three cases of intentional ingestion of an antiseptic liquid containing naphazoline there was acute pulmonary edema, altered mental status, hypertension, bradycardia, and sweating; two required mechanical ventilation and all of the clinical effects resolved within 24 hours [ 18 ]. The imidazoline derivatives, oxymetazoline, xylometazoline, tetrahydrozoline, and naphazoline, are found in topical ophthalmic and nasal decongestants available OTC. In published reports of naphazoline ingestion, clinical effects are hypertension, bradycardia, pallor, diaphoresis, and respiratory distress. Naphazoline (hydrochloride) SAFETY DATA SHEET Supersedes Revision:12/26/2017 according to Regulation (EC) No. 48. Do NOT use it … Naphazoline hydrochloride Revision Date 19-Jan-2018 Precautionary Statements Prevention Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Ingestion IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Rinse mouth Storage Store locked up Disposal 2009 May-Jun. Accidental oral ingestion in infants and children may lead to coma and marked reduction in body temperature. drowsiness. Pre-registered substances Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. Naphcon … I found the information and suggest the Puppy see the ER Vet as the main ingredient Naphazoline Hydrochloride is toxic if ingested. These side effects may go away during treatment as your body adjusts to the medicine. naphazoline are frequently used as local vasoconstrictive and decongestant drugs. 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