Consider therapy modification, Calcium Channel Blockers (Nondihydropyridine): May enhance the hypotensive effect of Beta-Blockers. Recommendations for other alpha2-agonists are unavailable. Solution; Ophthalmic; Brimonidine Tartrate 2 mg; Dorzolamide Hydrochloride 20 mg; Timolol Maleate 5 mg / ml: Medical categories: Human: Alpha-adrenergic agonists; Antiglaucoma preparations; EENT drugs, miscellaneous: Indications and usages, anatomical therapeutic chemical and diseases classification codes: S01ED51 - Timolol, combinations Last updated on Sep 21, 2020. Use eye drops before eye ointments to allow the eye drops to enter the eye. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Brimonidine works by allowing better fluid drainage from within the eye and also by decreasing the amount of fluid formed in the eye. Monitor therapy, Alpha2-Agonists: May enhance the AV-blocking effect of Beta-Blockers. It is thought that Brimonidine Tartrate lowers IOP by enhancing uveoscleral outflow and reducing aqueous humour formation. Combigan eye drops contain the active ingredients brimonidine (0.2%), an alpha-2 adrenergic agonist and timolol (0.5%). Monitor therapy, Suvorexant: CNS Depressants may enhance the CNS depressant effect of Suvorexant. Withdraw beta blockers several days before clonidine withdrawal when possible, and monitor blood pressure closely. If you miss a dose of this medicine, apply it as soon as possible. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, 10 Ways to Prevent Diabetes-Related Eye Problems, Wet Age-Related Macular Degeneration and Vision Loss. The combination of Brimonidine tartrate and Timolol maleate is available with brand name Combigan (Allergen Plc, India) as eye drops containing Brimonidine tartrate 0.2% and Timolol maleate 0.5%. Brimonidine tartrate is an alpha-2 selective adrenergic receptor agonist for ophthalmic use. If more than 1 topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart. Monitor for signs/symptoms of heart failure and discontinue use immediately if suspected. Use your next dose at the regular time. Monitor therapy, Opioid Agonists: CNS Depressants may enhance the CNS depressant effect of Opioid Agonists. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Bradycardia and signs of heart failure have also been reported. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Monitor therapy, Beta2-Agonists: Beta-Blockers (Nonselective) may diminish the bronchodilatory effect of Beta2-Agonists. Timolol is a beta-blocker that also reduces pressure inside the eye. Note: In the Canadian labeling, use in children (at any age) is not recommended. • Angle-closure glaucoma: Appropriate use: Not for use alone to treat acute angle-closure glaucoma (has no effect on papillary constriction). What do I need to tell my doctor BEFORE I take Brimonidine and Timolol? For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. Consider therapy modification, Chlormethiazole: May enhance the CNS depressant effect of CNS Depressants. This medication should not be used if you have certain medical conditions. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Monitor therapy, Mirtazapine: May diminish the antihypertensive effect of Alpha2-Agonists. Note: This is not a comprehensive list of all side effects. Recommended dosage in adults (including the elderly) The recommended dose is one drop of Brimonidine Tartrate/Timolol in the affected eye(s) twice daily, approximately 12 hours apart. Use this medication regularly in order to get the most benefit from it. It belongs to a class of drugs known as alpha agonists. For the properties of the components please consider the following; TIMOLOL MALEATE; BRIMONIDINE TARTRATE… • Anaphylactic reactions: Use caution with history of severe anaphylaxis to a variety of allergens; patients taking beta-blockers may become more sensitive to repeated challenges. Avoid combination, Oxomemazine: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy, Alcohol (Ethyl): CNS Depressants may enhance the CNS depressant effect of Alcohol (Ethyl). This combination medication is used to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e.g., ocular hypertension). pill, oral solution, injection, inhaled medicine) and why it’s … Brimonidine Tartrate, Timolol Maleate Ophthalmic drops, solution What is this medicine? This medication may come with a Patient Information Leaflet. Copyright(c) 2020 First Databank, Inc. Monitor patient closely for evidence of CNS depression. • Hepatic impairment: Use with caution in patients with hepatic impairment; has not been studied. Brimonidine tartrate and Timolol maleate in pharmaceutical formulations using borate buffer pH 9.0. Management: Ruxolitinib Canadian product labeling recommends avoiding use with bradycardia-causing agents to the extent possible. Tilt your head back, look up, and pull down the lower eyelid to make a pouch. Consider therapy modification, HydrOXYzine: May enhance the CNS depressant effect of CNS Depressants. Elevated intraocular pressure: For the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy because of inadequately controlled IOP. Keywords: Niosomes, Brimonidine tartrate, Timolol maleate, treatment of glaucoma. WebMD does not provide medical advice, diagnosis or treatment. COMBIGAN (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha- adrenergic receptor agonist with a beta-adrenergic receptor inhibitor indicated for the reduction of elevated … Patients undergoing planned major surgery should be gradually tapered off therapy (if possible) prior to procedure. Management: Reduce the Intermezzo brand sublingual zolpidem adult dose to 1.75 mg for men who are also receiving other CNS depressants. • Thyroid disease: May mask signs of hyperthyroidism (eg, tachycardia). Available for Android and iOS devices. Drug interactions may change how your medications work or increase your risk for serious side effects. 26921-17-5 . Monitor therapy, Lemborexant: May enhance the CNS depressant effect of CNS Depressants. The properties listed on this page are those particular to the combination only. Monitor therapy, Cholinergic Agonists: Beta-Blockers may enhance the adverse/toxic effect of Cholinergic Agonists. Monitor therapy, Dimethindene (Topical): May enhance the CNS depressant effect of CNS Depressants. Some products that may interact with this drug include: beta blockers taken by mouth (e.g., propranolol), certain antidepressants (SSRIs such as fluoxetine, tricyclics such as amitriptyline), digoxin, epinephrine, fingolimod, high blood pressure medications (e.g., clonidine, methyldopa), quinidine. Brand Name(s): Combigan There may be other brand names for this medicine. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. Monitor therapy, Bromopride: May enhance the CNS depressant effect of CNS Depressants. Brimonidine Tartrate And Timolol Maleate Ophthalmic Solution 0.15%... ₹ 70/Bottle Get Quote Allopathic Brimonidine And Timolol Eye Drops, Packaging Type: Bottle For Clinical Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Brimonidine is more selective for the α-2 adrenoreceptor. Management: Dosage adjustments of lemborexant and of concomitant CNS depressants may be necessary when administered together because of potentially additive CNS depressant effects. Protect from light. Lowering high pressure inside the eye helps to prevent blindness. BRIMONIDINE; TIMOLOL (bri MOE ni deen; TYE moe lole) is used in the eye to treat open-angle glaucoma and high … Timolol lowers IOP … Tell your doctor or pharmacist if you are using other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Plasma concentrations of brimonidine peaked at 1 to 4 hours after ocular dosing. If you miss a dose, use it as soon as you remember. UV-1800 double beam UV-VIS spectrophotometer (Shimadzu) with a pair of 10mm path length matched quartz cells is used for the study. If combined, dose reduction or discontinuation of one or more CNS depressants (including the oxybate salt product) should be considered. Store at room temperature away from light. Monitor therapy, Rufinamide: May enhance the adverse/toxic effect of CNS Depressants. Consider therapy modification, Blonanserin: CNS Depressants may enhance the CNS depressant effect of Blonanserin. Consider therapy modification. Back to top. Avoid use with other CNS depressants at bedtime; avoid use with alcohol. (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% combigan.com For Providers Elevated intraocular pressure: Children ≥2 years: Ophthalmic: Instill 1 drop into affected eye(s) twice daily, Note: In the Canadian labeling, use in children (at any age) is not recommended. Consider therapy modification, Esketamine: May enhance the CNS depressant effect of CNS Depressants. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Avoid combination, Bupivacaine: Beta-Blockers may increase the serum concentration of Bupivacaine. Talk to your pharmacist for more details. Canadian product labeling specifically lists this combination as contraindicated. The risk associated with ophthalmic products is probably less than systemic products. If you develop an eye infection or injury, or have eye surgery, check with your doctor about whether you should continue to use your current bottle of this medication. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Monitor therapy, Ivabradine: Bradycardia-Causing Agents may enhance the bradycardic effect of Ivabradine. Keep all medications away from children and pets. Management: The manufacturer of Diclegis (doxylamine/pyridoxine), intended for use in pregnancy, specifically states that use with other CNS depressants is not recommended. Combigan eye drops are used to lower raised pressure in the eye and to treat glaucoma.. Glaucoma is a condition in which the pressure of the fluid in the eye may be high. Monitor therapy, EPINEPHrine (Systemic): Beta-Blockers (Nonselective) may enhance the hypertensive effect of EPINEPHrine (Systemic). These agents should only be combined if alternative treatment options are inadequate. Monitor therapy, Lisuride: May enhance the CNS depressant effect of CNS Depressants. Combigan (brimonidine tartrate/timolol maleate) 0.2%/0.5% is used to reduce IOP in … Monitor therapy, Cannabidiol: May enhance the CNS depressant effect of CNS Depressants. It belongs to a class of drugs known as alpha agonists. Timolol: Blocks both beta-1 and beta-2 adrenergic receptors, reduces intraocular pressure by reducing aqueous humor production or possibly outflow; reduces blood pressure by blocking … Monoamine Oxidase Inhibitors may increase the serum concentration of Brimonidine (Ophthalmic). Management: Dose reduction of suvorexant and/or any other CNS depressant may be necessary. Before having surgery, tell your doctor or dentist that you are using this medication. Before using this product, tell your doctor or pharmacist if you are allergic to brimonidine or timolol; or to apraclonidine; or if you have any other allergies. Brimonidine. Monitor therapy, MetyroSINE: CNS Depressants may enhance the sedative effect of MetyroSINE. Selected from data included with permission and copyrighted by First Databank, Inc. Beta-Blockers may enhance the rebound hypertensive effect of Alpha2-Agonists. Properly discard this product when it is expired or no longer needed. The recommended dose in adults is one drop of Brimonidine tartrate/timolol maleate ophthalmic solution in the affected eye (s) twice daily, approximately 12 hours apart. Dronedarone may increase the serum concentration of Beta-Blockers. Brimonidine and timolol ophthalmic (for the eyes) is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Methotrimeprazine may enhance the CNS depressant effect of CNS Depressants. Posology. You may report side effects to Health Canada at 1-866-234-2345. Management: Consider alternatives to this combination when possible. Tell your doctor right away if any of these unlikely but serious side effects occur: vision changes, eye sensitivity to light, eye pain/swelling/discharge, slow/irregular heartbeat, muscle weakness, unusual tiredness, mental/mood changes, coldness/numbness/pain in the hands or feet, swelling ankles/feet, sudden unexplained weight gain, shortness of breath. To help you remember, use it at the same times each day. Monitor therapy, Brimonidine (Topical): May enhance the CNS depressant effect of CNS Depressants. (structure of brimonidine tartrate) (structure of timolol maleate) CAS Registry No. Adv Ther. Monitor therapy, Brexanolone: CNS Depressants may enhance the CNS depressant effect of Brexanolone. Consider therapy modification, Monoamine Oxidase Inhibitors: May enhance the adverse/toxic effect of Brimonidine (Ophthalmic). Monitor therapy, Methacholine: Beta-Blockers may enhance the adverse/toxic effect of Methacholine. • CNS depression: May cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery or driving). Monitor therapy, Epinephrine (Racemic): Beta-Blockers (Nonselective) may enhance the hypertensive effect of Epinephrine (Racemic). Brimonidine is more selective for the α-2 adrenoreceptor. Calcium Channel Blockers (Nondihydropyridine) may increase the serum concentration of Beta-Blockers. Monitor therapy, Nabilone: May enhance the CNS depressant effect of CNS Depressants. oozing in the eye redness, swelling, or itching of the eye or eyelid runny or stuffy nose seeing flashes or sparks of light seeing floating dark spots or material before eyes seeing floating spots before the eyes or a veil or curtain appearing across part of vision skin rash sneezing sweating swelling of the eye … • Vascular insufficiency: Can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease, Raynaud disease, and thromboangiitis obliterans.