Exposure to DBP induces the toxicity in early development and adverse effects on cardiac development in zebrafish (Danio rerio). We demonstrate that Phox2b is capable of regulating itself as well as ascl1, and that phox2b deficiency uncouples this autoregulatory mechanism, leading to inhibition of sympathetic neuron differentiation. However, the increased incidence of antibiotic resistance and the solubility issues associated with naturally derived therapeutic drugs have propelled the scientific community to quest for novel platforms for the delivery of drug moieties that bypass the resistance mechanisms. However, its biological effects including in vivo embryonic toxicity and tissue regenerative properties are relatively unknown. The differentially expressed genes affected by Cd2+ were analyzed by using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to study the regulated pathways. However, plastic pollution remains challenging to monitor in the environment and to control under laboratory conditions, and plastic particles are often naturally or experimentally co-contaminated with diverse chemical pollutants. Learn about our remote access options, Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China, College of Life Science, Henan Normal University, Xinxiang, China. DNA polymerases may therefore be potential targets to increase the sensitivity of cancer cells to chemotherapy drugs. The results showed that photocatalytic treatment with 0.1 mg/L of ACP-TiO2 9% for 7.5 h is sufficient to eliminate DCF (50 mg L−1) and its by-products from water. In addition, the high quality of this genome assembly provides a clearer understanding of key genomic features such as a unique repeat content, a scarcity of pseudogenes, an enrichment of zebrafish-specific genes on chromosome 4 and chromosomal regions that influence sex determination. Danio rerio as a Model in Aquatic Toxicology and Sediment Research; Published: 31 August 2014; Zebrafish as a model to study the role of DNA methylation in environmental toxicology. were stained with hematoxylin-eosin and investigated by light microscopy. Taken together, our results suggest that TALEN technology provides a robust alternative to CoDA ZFNs for inducing targeted gene-inactivation in zebrafish, making it a preferred technology for creating targeted knockout mutants in zebrafish. Danio rerio Therefore, our understanding of the effects of virgin MP/NP in freshwater and marine fish is still limited. Our studies demonstrate that the major mechanisms used to repair DNA DSBs are conserved from zebrafish to mammal, and zebrafish provides an excellent model for studying and manipulating DNA DSB repair at the organismal level. Purpose of review The zebrafish pronephros provides an informative vertebrate model system for studying renal development and function as well as a rapid screening tool for identification of genes important to the physiology and pathophysiology of the vertebrate kidney. The industry is increasingly relying on fish for toxicity assessment. Developmental BPA exposure in larvae dose-dependently reduced food-intake and locomotion and increased energy expenditure. This unique set of attributes makes the zebrafish model system particularly valuable for the study of muscle diseases. It is noteworthy that the present research explored the correlation among the three indicators induced by endosulfan. hyperplasia, desquamation, curling of secondary lamellae, hemorrhage, aneurysm, edema, epithelial Another way of utilizing zebrafish as a model system to study heritable skin diseases is to perform “knockdown” of the expression of specific genes by stable morpholino-based antisense oligonucleotides (Figure 3). Zebrafish Models in Neural and Behavioral Toxicology across the Life Stages. They do, however, also offer many advantages for the study of neuronal circuitry because the larvae are transparent, allowing optical studies of neuronal activity and noninvasive photoablations of … ... [22,23]). Furthermore, parallel experiments with microinjections of osteonectin-capped RNA showed that malformations induced by osteonectin overexpression were similar to those observed after a UVR exposure. It is therefore becoming increasingly necessary to develop methods for screening these materials for possible toxic effects. In particular, essential oils and some of their chemical constituents such as terpenoids and phenylpropanoids offer distinct advantages. The rise of zebrafish as a toxicological model in the last twenty years is an excellent example of convergence and persistence. The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) could affect embryonic development in zebrafish 69. reported that PFOA exposure changed the expression of the fatty acid–binding protein gene and affected the levels of liver triglyceride 70. This review introduces recent work on different DNA damage and repair studies in zebrafish, with special emphasis on the role of BER in zebrafish early embryological development. With this work we show that zebrafish embryos can biotransform CDNB to the respective glutathione conjugate as early as 4 hours post fertilization. The study aims to review the toxicity analysis of these rare earth elements concerning aquatic biota, considering it to be the sensitive indicator of the environment. In vivo studies represent an essential step in drug development and currently rely largely on mice, yet limitations of mammalian models motivated the search for complementary vertebrate model systems. Zebrafish as a new animal model in Toxicology: advantages and limitations The zebrafish is a small tropical fish native of northern India and adjacent countries. This is because, aside from the well-characterized genome of zebrafish and the availability of a broad range of experimental and computational research tools, they are exceptionally well suited for high-throughput approaches. In the present study, zebrafish embryos and larvae were used as a model to investigate the sublethal and lethal effects of three different organochlorine pesticides, namely methoxychlor, endosulfan and heptachlor, as well as the flame retardant tetrabromobisphenol A, and its precursor compound bisphenol A. However, the limitations of the tiered test are that it is time‐consuming and labor‐intensive, and it requires professional personnel. 11-17 ... and organic pollutants for toxicology. Toxic heavy metals could be detected indirectly in the aquatic environment by monitoring enzymes' activity or biomarker gene expression in wild‐type embryos or adult zebrafish. 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