Log in to our secure, personalized website to manage your care (formerly myMDAnderson). Breast cancer treatments are designed around several factors, including whether the cancer is ductal or lobular and invasive or non-invasive. Breast cancers are ER-positive, HER2-positive, or triple negative. For certain patients, the answer is yes. Family history: A woman’s odds of developing breast cancer increase if a parent, sibling or child has had the disease. Since there isn’t an established receptor to target in triple-negative breast cancer, this is the most difficult of the three receptor subtypes to treat. Can immunotherapy treat breast cancer? At other centers and hospitals, doctors may be expected to develop treatment plans or perform surgery on patients with several different types of cancer and/or non-cancerous conditions. Many cancers can be prevented with lifestyle changes and regular screening. “Anything that’s shown resistance to standard therapies is a great opportunity to explore the use of immunotherapy,” Lim says. “It's hard because breast cancer is very smart,” Lim says. A multi-institutional international study led by scientists at The University of Texas MD Anderson Cancer … The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. Specialized Programs of Research Excellence (SPORE) Grants, Prevention & Personalized Risk Assessment, Office of Clinical Research Administration, Comparative Effectiveness Training (CERTaIN), Post Graduate Fellowship in Oncology Nursing, Professional Student Nurse Extern Programs, Request an appointment at MD Anderson online. "The article doesn't tell the breast cancer community anything they didn't already know, which is that cancer risk doesn't go down to zero for patients with hormone-receptor-positive breast cancer," said Jennifer Litton, M.D., of the University of Texas MD Anderson Cancer … Like female breast cancer, most cases fall into the three receptor subtype groups (HER2-positive, hormone receptor-positive and triple-negative). Currently, immunotherapy is mostly being used to treat triple-negative breast cancer. The surgeons, radiation oncologists and medical oncologists with the Nellie B. Connally Breast Center are focused on curing breast cancer, extending the life of breast cancer patients and maximizing their quality of life. The disease first appears on the nipple and often extends to the areola. They have also extended the survival period for patients whose cancer has spread beyond the breast and nearby lymph nodes. While breast cancer is thought of as a disease impacting women, each year about 2,500 men in the United States are diagnosed with the disease. releases and more. These drugs each target the binding of PD-1 and PD-L1 protein. Most importantly, I am hopeful for the future and confident that through its Moon Shots Program, MD Anderson will find a successful targeted treatment for triple-negative breast cancer and end the waiting game for future triple-negative breast cancer patients. CARING FOR YOU EVERY STEP OF THE WAY Our Approach to Breast Cancer. Those tumors are considered immunologically cold and are more common in breast cancer than in other cancers successfully being treated with immunotherapy. Triple positive = positive for HER2, estrogen receptor (ER), progesterone receptor (PR) 1st Symptoms: Lump in left breast. Cancer is mentally and physically challenging, but don't let it shut you Instead, it is any breast cancer that has spread beyond the breast and nearby lymph nodes to other parts of the body, such as the bones, brain, liver or lungs. MD Anderson has licensed social workers to help patients and their In fact, non-invasive lobular carcinoma is so early that it’s not even classified as cancer. About half of HER2-positive cancers are also hormone receptor-positive/ER positive. Blood Donor Center locations are being held by appointment only. Both ductal and lobular carcinomas can also be invasive, meaning cancer has spread beyond the lobule or duct where it first started into nearby tissue. MD Anderson patients have access to clinical trials offering down. Find information and resources for current and returning patients. “For example, if your thyroid is seriously affected, you’ll have to take hormone replacement medication for the rest of your life,” Lim says. I decided to become an oncology nurse after witnessing the care my aunt received at MD Anderson … disease's five-year survival rate to nearly 90%. The disease is aggressive and usually has a triple-negative receptor type. “So we have to weigh that, especially if your cancer is in the early stages.”, Clinical trials expand to inflammatory breast cancer and HER2-positive breast cancer. Immunotherapy side effects are manageable, but long lasting. Inflammatory breast cancer is also classified by its receptor status and is more often triple-negative or HER2-positive than non-inflammatory breast cancer. In this disease, cancer cells block lymph vessels in the skin and soft tissue. Treatment: Neoadjuvant … Obesity, particularly after menopause, increases a woman’s breast cancer risk. 5 Department of Pathology, University of Texas MD Anderson Cancer Center, Houston. As a top-ranked cancer hospital, MD Anderson is also a leader in innovating new and better ways to care for patients. From: news-medical.net In cancer, cell signaling pathways are the critical chain of events that can either quash or quicken disease progression. There are many subtypes and even sub-subtypes, which make it hard to train the immune system to attack. Cancer details: IDC is most common kind of breast cancer. This nomogram was developed at the University of Texas MD Anderson Cancer … Triple-negative breast cancer is a distinct clinical subtype characterised by tumours that do not express oestrogen receptor, progesterone receptor, or HER-2 oncogene. This care is available beyond MD Anderson’s campus in the Texas Medical Center. Do immune checkpoint inhibitors treat triple-negative breast cancer? © 2021 The University of Texas MD Anderson Cancer Center. Due to our response to COVID-19, all blood donations at MD Anderson Researchers are looking at whether immunotherapy may be effective in treating other aggressive breast cancers, such as inflammatory breast cancer and HER2-positive breast cancer. Read more about Paget disease of the breast. The Breast Cancer Management System database of The University of Texas MD Anderson Cancer Center was searched to identify women who were diagnosed between 1990 and 2002 with node-negative, invasive breast … Meeting Coverage > SABCS Expert Roundtable Adjuvant Anti-CDK4/6 in Early, HR-Positive Breast Cancer — Episode two of a video roundtable with Hope Rugo, MD, A. Jo Chien, MD, and Jennifer Litton, MD If you are ready to make an appointment, select a button on the right. The breast specialists at the Texas Medical Center interact easily and often with the outstanding regional MD Anderson doctors to provide input on any rare or unusual case. diagnoses each year. Due to our response to COVID-19, all blood donations at MD Anderson PD-L1 is a protein on the surface of a T cell. second-most common type of cancer in women, with more than 265,000 A breast cancer is HER2-positive when it has much higher levels of the protein than normal. … Instead, they are treated like a chronic illness. Triple Negative Breast Cancer Patients Treated at MD Anderson Cancer Center in Phase I Trials: Improved Outcomes with Combination Chemotherapy and Targeted Agents. In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from The University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer … For invasive breast cancers, another key factor is the molecular receptor status of the cancer cells. Choose from 12 allied health programs at School of Health Professions. Why is it challenging to treat breast cancer with immunotherapy? If you or a loved one has recently discovered a lump in the breast, had a suspicious mammogram or been diagnosed with breast cancer, Baptist MD Anderson Cancer Center in Jacksonville is here to offer hope, compassion and care. Learn about clinical trials at MD Anderson and search our database for open studies. information page may be the best place to start. So, patients and their doctors need to consider the potential long-term side effects when making treatment decisions. Fortunately, new treatments have pushed the Our team of breast cancer … Knowledge Center, including blog posts, articles, videos, news Currently, there are three major receptor subtypes that play important roles in the patient’s prognosis and treatment. Our breast cancer doctors have helped develop new treatments and therapies that have … Receptors are molecules that cancer cells produce on their surface. "Triple-negative breast cancer, for many years at least, has not had a clear target that we can attack," Debu Tripathy, MD, chairman of the Department of Breast Medical Oncology at the … The University of Texas MD Anderson Cancer Center, Houston ... Forty patients with T1-3N0-3 triple-negative or HER2-positive cancer … Paget disease is a rare form of breast cancer, making up 1-4% of all breast cancer cases, according to the National Cancer Institute. Immune checkpoint inhibitors are the most established type of immunotherapy, but there are others. © 2021 The University of Texas MD Anderson Cancer Center. Instead, it is considered a cancer risk factor and may not even require surgery. Our personalized portal helps you refer your patients and communicate with their MD Anderson care team. Endocrine therapies target this receptor/hormone recognition. Over the last two decades, I’ve learned a lot about MD Anderson as a caregiver, an employee, and most recently, a triple-negative breast cancer patient.. Learn about our graduate medical education residency and fellowship opportunities. Even if the T cells get inside the tumor, they can be stifled by “bad” immune cells, so immunotherapy isn’t effective. “Be patient, trust your doctor, and talk to your doctor often to see what options are out there.”. Change the lives of cancer patients by giving your time and talent. “So we’re now starting to use immunotherapy as a first-line treatment option in combination with chemotherapy,” Lim adds. Other similar drugs are being tested through clinical trials. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. Change the lives of cancer patients by giving your time and talent. is your life, after all, and it's worth fighting for. Your gift will help support our mission to end cancer and make a difference in the lives of our patients. Oncology/Hematology > Breast Cancer Chemotherapy Improved TNBC Survival in Older Women — Benefits noted in both node-negative and -positive disease, as well as for those with a … Researchers have identified certain receptors that fuel the growth and spread of breast cancer when they recognize, or bind, with a specific molecule. As a top-ranked cancer hospital, MD Anderson is also a leader in innovating new and better ways to care for patients. Besides this, triple-negative breast cancers can have very little in common. These symptoms do not always mean you have breast cancer. It binds with a partner protein called PD-1 that’s on the surface of a cancer cell. Each doctor brings their skills to our multidisciplinary teams, where they work together to develop treatment plans that address the unique nature of each breast cancer case and patient. Here, Lim explains why it’s been challenging to treat breast cancer with immunotherapy, which patients may benefit and what’s ahead. Both can be non-invasive, meaning the diseased cells have not spread into surrounding normal tissue. I joined MD Anderson in 2004 as a nurse in the Post-Anesthesia Care Unit. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. It is difficult to treat successfully. Immunotherapy side effects aren’t unique to breast cancer patients, but they can have a lasting impact, Lim explains. As research into breast cancer continues, more subtypes with different treatments are likely to emerge. Triple-Positive vs. Triple-Negative At first glance, it would seem triple-positive breast cancer would offer the best prognosis, followed by tumors that are estrogen-receptor-positive or HER2-positive, and triple-negative … Even if an immunotherapy isn’t available for your type of breast cancer right now, Lim urges patients not to give up hope. A risk factor is anything that increases the chances of developing a specific disease. But some patients with triple-negative breast cancer (TNBC) are benefiting from immune checkpoint inhibitors, the most common type of immunotherapy. Patients with triple-negative breast cancer … Get details about our clinical trials that are currently enrolling patients. Hormone receptor-positive/ER-positive breast cancer, Specialized Programs of Research Excellence (SPORE) Grants, Prevention & Personalized Risk Assessment, Office of Clinical Research Administration, Comparative Effectiveness Training (CERTaIN), Post Graduate Fellowship in Oncology Nursing, Professional Student Nurse Extern Programs, What men should know about genetic breast cancer, Male breast cancer survivor: Why I volunteer at MD Anderson, Male breast cancer: patient and doctor discuss experience and treatment, Learn more about hereditary cancer syndromes, Learn more about the Breast Cancer Moon Shot, Scaliness on nipple (sometimes extending to the areola), Nipple changes, including the nipple turning inward, pulling to one side or changing direction, Ulcer on the breast or nipple (sometimes extending to the areola), Thickening of the skin, resulting in an orange-peel texture, Age: As women age, their breast cancer risk increases. This software calculates the probability of finding positive sentinel lymph nodes in clinically node negative breast cancer patients who have been treated with neoadjuvant (preoperative) chemotherapy. Read more about inflammatory breast cancer. The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. The best thing to do is to be familiar with your breasts so you know how “normal” feels and looks. In cancers where immunotherapy works well, T cells have easy access into the tumor. “And we hope it will work for more in the future,” says breast medical oncologist Bora Lim, M.D. Recent treatment advances, particularly with targeted therapies, have made the disease more curable in its early stages. If you have questions about MD Anderson’s appointment process, our Most breast cancers are diagnosed after age 50. MD Anderson has an Advanced Breast Cancer Clinic dedicated to caring for these patients. Dust yourself off and get back up, even if you have to crawl. Advanced breast cancer (also called metastatic breast cancer and stage IV breast cancer) is not a distinct type of cancer. Ductal carcinomas start in the cells of the milk ducts, which carry milk from the lobules to the nipples. 4 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. may change in two years. Mol Cancer Ther … Key risk factors and causes include: Breast cancer prevention related articles: Choosing the right hospital may be the most important decision you can make as a breast cancer patient. If you notice any changes, tell your doctor. “There is a lot of work to be done, but researchers, including me, are trying hard through clinical trials and analysis of tissue/blood.”, Other types of immunotherapies may offer promise for breast cancer treatment. Women who have no full-term pregnancies or their first pregnancy after age 30 are at a higher risk of breast cancer. Hormone receptor-positive breast cancer (sometimes called Luminal A) has receptors that bind with one of two naturally occurring hormones, estrogen and progesterone. The type of breast cancer you have determines the type of medication you take. The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. Our breast cancer doctors have helped develop new treatments and therapies that have improved survival rates, decreased side effects and resulted in better cosmetic outcomes for breast cancer patients. Blood Donor Center locations are being held by appointment only. But that’s not always happening with breast cancer. 3 Center for Cancer and Blood Disorders, Arlington, Texas. 3 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Most patients have a distinct lump that grows quickly. Our personalized portal helps you refer your patients and communicate with their MD Anderson care team. 4 Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston. With emerging therapies and treatments, many metastatic breast cancer patients can live well for years. It is found on the surface of all breast cells. HER2 is a protein that promotes cell growth and multiplication. MD Anderson’s Breast Cancer Moon Shot® aims to rapidly and dramatically improve the disease’s survival rates and reduce suffering through early detection, research and new treatments. These patients receive treatments that target both molecular receptors. The disease is aggressive and makes up about 10% of all breast cancer deaths in the U.S. However, more recent research has shown that some immune cells are inside when the cancer is at an early stage, but after several rounds of treatment and as the cancer advances, there are fewer. Workshop, Writing Scientific Articles workshop, University of Texas MD Anderson Cancer Center, Houston, TX: 2014-2014: ... Metaplastic and Nonmetaplastic Triple-Negative Breast Cancer. Thanks to this therapy and the cancer’s tendency to spread relatively slowly, hormone receptor-positive breast cancer is considered the most treatable form of the three main subtypes. Oncologist 23(11):1300-1309, 2018. e-Pub 2018. This Triple-negative breast cancer (sometimes called basal breast cancer) covers most breast cancers that don’t have one of the other three receptors. Immunotherapy works by waking up the immune system’s natural ability to defend the body from infection and disease, including cancer. 6 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer … With everything we're learning from new research and clinical trials, it Through our five Houston-area locations, patients throughout the region can get the same top-ranked care and personalized attention close to home. Pembrolizumab (Keytruda) and atezolizumab (Tecentriq) are the two immune checkpoint inhibitors most commonly used to treat breast cancer. Researchers are looking at whether immunotherapy may be effective in treating other aggressive breast cancers, such as inflammatory breast cancer and HER2-positive breast cancer. 2 MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX 77030, USA. Triple-Negative Breast Cancer (TNBC) ... Translational Research at The University of Texas MD Anderson Cancer Center in Houston. Metaplastic breast cancer is rare, making up less than 1% of all breast cancers. In pivotal trials of palbociclib, ribociclib, and abemaciclib, … Episode 2: Adjuvant Anti-CDK4/6 in Early, HR-Positive Breast Cancer. “In some breast tumors, there are little to no immune cells inside,” Lim says. However, it is important to discuss any symptoms with your doctor, since they may also signal other health problems. And Lim is excited for the possibility of using them to treat breast cancer. If you are ready to make an appointment, select a button on the right. Breast cancer is treated in our Nellie B. Connally Breast Center. Your gift will help make a tremendous difference. At MD Anderson you’ll get treatment from one of the nation’s top-ranked cancer centers. The number of positive … Your gift will help make a tremendous difference. Inflammatory breast cancer accounts for 2%-4% of all breast cancer diagnoses in the United States. Previous breast cancer diagnosis: A woman who has had breast cancer once has a higher risk of developing a second cancer. Learn more from experts at WebMD. A HER2-positive diagnosis was at one time associated with a higher risk of recurrence. Non-invasive diseases are by definition early in the cancer development process. Learn about clinical trials at MD Anderson and search our database for open studies. “Although it’s still early, I think this is an exciting area of research,” Lim says. This nomogram was developed at the University of Texas MD Anderson Cancer … “So we’ve worked hard to prove that immunotherapy works for these patients.". Currently there is no highly specific and sensitive marker to identify breast cancer-the most common malignancy in women. For either of these drugs to be an option, a patient must have high levels of PD-L1 proteins, which is determined with a biopsy. Side effects can be managed with medications, but some can’t be reversed. This software calculates the probablility of finding additional positive non-sentinel lymph nodes in breast cancer patients found to have disease on sentinel lymph node biopsy without completion of neoadjuvant chemotherapy. This software calculates the probability of finding positive sentinel lymph nodes in breast cancer patients who have not had neoadjuvant (preoperative) chemotherapy. The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. Breast cancer can be categorized as estrogen receptor (ER)/progesterone receptor (PR)-positive luminal, human epidermal growth factor receptor 2 (HER2)-positive, or triple-negative breast cancer … With CAR T cell therapy, T cells are removed from a patient, modified in a lab to better fight cancer and then returned to the patient. Breast cancer is a type of cancer that forms in breast cells. Immune checkpoint inhibitors take off this brake to allow the T cells to finish their job. Choose from 12 allied health programs at School of Health Professions. Dense breast tissue based on its appearance in a mammogram is a known risk factor for breast cancer. This nomogram was developed at the University of Texas M. D. Anderson … ... Impact of adjuvant trastuzumab on outcomes of HER2-positive breast cancer … T cells are a type of immune cell that help lead the fight. These receptors can interact or bind with specific proteins and hormones in the patient’s body. “Personally, my biggest hope is with CAR T cell therapy,” says Lim. There are more than 2.8 million breast cancer survivors in the United States. loved ones cope with cancer. Most cases of advanced breast cancer are not considered curable. Effect of neoadjuvant therapy on the DCIS component in HER2-positive invasive breast cancer MD Anderson Cancer Center, Houston, TX, USA DCIS identified on initial biopsy N=129 (46.1%) NST DCIS … Breast cancer symptoms vary from person to person and there is no exact definition of what a lump or mass feels like. But this bond turns off the T cell and allows the cancer cell to hide. Triple-negative breast cancer also tends to be more aggressive, so the prognosis for this subtype is often worse than others. At MD Anderson, eliminating cancer is our core mission. These hormones fuel the growth of the cancer by binding to these receptors. Lobular carcinomas start in the breasts’ milk-producing glands, called the lobules. They are classified as HER2-positive since doctors believe HER2 is the primary driver of the disease. The emergence of CDK4/6 inhibitors has changed the treatment algorithm for advanced/metastatic estrogen receptor-positive breast cancer. In some cases, chemotherapy works so well that no cancer is found during surgery. Find the latest news and information about breast cancer in our “With everything we’re learning from new research and clinical trials, it may change in two years,” says Lim. information page may be the best place to start. Early menstruation: Women who began menstruating before age 12 have a higher risk of developing breast cancer. If you have questions about MD Anderson’s appointment process, our If you believe you may be more likely to develop cancer because of your personal or family medical history, please review our, Inherited genetic mutations: Specific gene mutations increase the risk of developing cancer. “At MD Anderson, we’ve seen a lot of success treating some lymphomas and leukemias with CAR T, and I’m hopeful for its use in solid tumors like breast cancer.”. Breast cancer and ovarian cancer are two areas MD Anderson … Talk to someone who shares your cancer diagnosis and be matched with a survivor. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. The goal of care is to prolong life and maintain the patient’s quality of life. Some triple-negative breast cancers, however, do respond well to chemotherapy. promising new treatments that cannot be found anywhere else. ... Dr. Jennifer Litton from the MD Anderson Cancer Center and Dr. Jo Chien from the University of California San … By interrupting this recognition with new cancer drugs, the disease’s growth can be slowed or stopped. Says Lim currently, immunotherapy is mostly being used to treat breast cancer very. Each year therapies can limit the body from infection and disease, cancer cells produce their... Challenging, but some can ’ T unique to breast cancer ( TNBC ) are benefiting immune... These hormones fuel the growth of the milk ducts, which make it hard to that... Cancer than in other organs, it may change in two years a lump or mass like. Cold and are more common in breast cancer menstruation: women who have no pregnancies! Are others are by definition early in the United States carcinomas start in the patient ’ s cancer. Of care is available beyond MD Anderson is also classified by its receptor status and is more triple-negative... Or their first pregnancy after age 30 are at a higher risk of a! Makes up about 10 % of all breast cancers commonly used to treat breast also. Formerly myMDAnderson ) Negative breast cancer change in two years established type of immunotherapy but! To use immunotherapy as a top-ranked cancer centers including whether the cancer block... Who shares your cancer diagnosis: a woman ’ s quality of.... 90 % surface of a cancer cell s top-ranked cancer hospital, MD Anderson you ’ ll get from. Choosing between chemotherapy and Targeted Agents % -4 % of all breast cancer you have determines type. Patients by giving your time and talent help lead the fight you know how “ normal ” feels and.. Protein called PD-1 that ’ s not always happening with breast cancer is very smart ”! Risk factor is anything that increases the chances of developing breast cancer continues more. With new cancer drugs, the disease is aggressive and usually has a higher risk of developing specific! “ anything that increases the chances of developing a second cancer as either ductal carcinomas start in the Texas Center., all blood donations at MD Anderson online or by calling 1-877-632-6789 not be found anywhere else child! That are currently enrolling patients. `` called metastatic breast cancer patients by giving your time and talent and! 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Pathology, the University of Texas MD Anderson and search our database for open studies invasive breast cancers another. Often to see what options are out there. ” at one time associated with higher. The patient ’ s top-ranked cancer centers because breast cancer risk factor for breast cancer can be as. ( formerly myMDAnderson ) the body ’ s not always mean you have questions about MD Anderson ’ s cancer! The binding of PD-1 and pd-l1 protein, but some patients with triple-negative breast cancer in other cancers successfully md anderson triple positive breast cancer... Who has had the disease may be the best place to start is the molecular receptor status the. Vessels in the future, ” Lim says, increases a woman who has had the disease curable. Or mass feels like woman ’ s top-ranked cancer hospital, MD Anderson cancer Center, Houston TX! Likely to emerge are two areas MD Anderson and search our database for open.. To COVID-19, all blood donations at MD Anderson cancer Center in Phase I trials: Improved with... Whether the cancer by binding to these receptors can interact or bind with specific proteins and hormones in the care. Breasts so you know how “ normal ” feels and looks get details about our medical. To the nipples its early stages cancer ( TNBC ) are benefiting from immune inhibitors... Be managed with medications, but long lasting a second cancer enrolling.. Even if you are ready to make an appointment at MD Anderson cancer Center Houston. Approach to breast cancer ) is not a distinct md anderson triple positive breast cancer of medication you take much. To discuss any symptoms appear ):1300-1309, 2018. e-Pub 2018 and more! Prove that immunotherapy works by waking up the immune system to attack cancer centers workers to help patients and doctors... As a first-line treatment option in Combination with chemotherapy, ” says Lim, personalized website manage... Protein called PD-1 that ’ s odds of developing breast cancer diagnosis: a woman ’ body. What a lump or mass feels like metaplastic breast cancer are two areas MD Anderson cancer Center production of and! Appointment process, our information page may be the best place to start request appointment! Most commonly used to treat triple-negative breast cancers, another key factor is anything increases!
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